Database Description. BACKGROUND Multivariate regressions were used to examine potential risk factors and quantify the economic impact of IRs. Conclusions: The MarketScan Commercial Claims and Encounters Database is a research database owned by Truven Health Analytics. Working off-campus? Filled prescriptions of sumatriptan, naratriptan, and sumatriptan/naproxen sodium during the pregnancy episode were identified by National Drug Codes using pharmacy dispensing claims. Data Source . Gout patients were seen most frequently by internists and family medicine practitioners. All HTN patients with ≥3 rounds of treatment options (vs single/initial round) had 3.8-fold higher next-year HTN complications’ risk (p-value < 0.0001). Integration of genomics, transcriptomics, radiomics, pharmacogenomics, and interactomics (protein–protein interactions) are essential for successful drug discovery. For the 296 first‐trimester sumatriptan/naproxen sodium exposures in the claims analysis, 3.7% of outcomes were elective abortions, 18.9% were spontaneous abortions, 1.4% were stillbirths, and 76.0% were livebirths. Use of anti-TNF agents, corticosteroids, and immunomodulators within 90 days of surgery was identified using Healthcare Common Procedure Coding System codes. We describe experimental technologies for AD drug discovery including human induced pluripotent stem cells, transgenic mouse/rat models, and population‐based retrospective case–control studies that may be integrated with multi‐omics in a network medicine methodology. The accurate determination of the frequency and severity of treatment-related complications is vital to informing patients and clinicians in their decision-making process. We further consider how this endophenotype network framework can provide advances in computational and experimental strategies for drug‐repurposing and identification of new candidate therapeutic strategies for patients suffering from or at risk for AD. Truven MarketScan is the most recent database to be installed on CTSC servers. It provides information, analytic tools, benchmarks, research, and services to the healthcare industry, including hospitals, government agencies, employers, health plans, clinicians, pharmaceutical, biotech and medical device companies. IBM MarketScan Research Databases. Younger patients (aged <15 years) were underrepresented in the CEMR compared with the NAMCS. The findings of this study support an approach of using existing health care database (s) in the post‐approval assessment of medication exposure in pregnancy. Sample data elements include demographic data (age, gender, employment status, geographic location), inpatient and outpatient medical information … Database Name: MarketScan® Commercial Claims and Encounters and Medicare Supplemental and Coordination of Benefits. Marketscan Commercial Claims and Encounters and Medicare Supplemental Databases; The IBM® MarketScan® Research Databases are one of the largest proprietary collections of de-identified US patient data available for healthcare research. Among live‐born infants linked to birth mothers, the frequency of major birth defects was determined overall and stratified by earliest trimester of exposure to sumatriptan, naratriptan, and sumatriptan/naproxen sodium. Truven Health Analytics is an IBM Watson Health Company that provides healthcare data and analytics services. This criterion would exclude infants that die during the first year of life (perhaps due to serious congenital malformations or other causes). Conclusions. However, the numbers of major birth defects found in stillbirths and induced abortion in the registry were very small. Administrative data provide a vast, accessible history of patient data, but are limited in the ability to accurately capture diagnosis and causality, and are subject to differing interpretations of billing codes. Sample data elements include demographic data (age, gender, … IBM MarketScan Research Databases at UCSF (formerly Truven Health Analytics Inc.) Data Description . During the 12‐month period prior to the pregnancy episode, 25.7% of sumatriptan‐exposed women had dispensing of nonsteroidal anti‐inflammatory agents while 49.2% had dispensing of opioids. Patients aged 18 to 64 years who underwent elective laparoscopic or open colectomy from January 1, 2010, through December 31, 2010, were included. Selected treatment patterns were risk-assessed using predictive modeling and/or literature-based recommendations. These claims data are collected from several hundred insurance providers, … Among both commercially insured and Medicaid-insured women, the likelihood of having HS vs LS increased over time. There is a need for alternative and or complementary methodological approaches to evaluating the safety of medications during pregnancy. However, the number of visits for males was significantly higher in the CEMR (CEMR: 270.8 and NAMCS: 239.0). New (n = 200,786) or all (n = 4.1 million) HTN patients were identified from 2015, 2016 enrollments in a nationwide administrative claims’ database and compared for HTN-specific treatment (Rx) choices, Rx count, and distinct rounds o f treatment o ptions ( ROTO ), respectively. Ann Arbor, MI: Truven Health Analytics Inc.; 2015, This study estimated the prevalence of maternal depressive symptoms and tested associations between maternal depressive symptoms and healthcare utilization and expenditures among United States publicly insured children with chronic health conditions (CCHC). The purpose of our study is to use the Truven MarketScan database to: 1) report the incidence of VTE, including DVT and PE, in patients undergoing simple knee arthroscopy and anterior cruciate ligament (ACL) reconstruction, and 2) evaluate combined oral contraceptive (COCP) use as a potential risk factor for VTE in patients undergoing knee arthroscopy. To read the full-text of this research, you can request a copy directly from the authors. Co-morbidities/persistence of ≥3 rounds of treatment options over 2 years further increased these odds and total medications/chronic disease score correlated with ROTO counts. MarketScan is a de-identified commercial insurance claims database representing 30–50 million persons per year from >160 large employers and health plans representing all 50 US states . The Truven MarketScan Database, which includes inpatient and outpatient claims from prescriptions, procedures, and laboratory results from over 122 million unique individuals beginning in 1999, was analyzed. Utilizing existing electronic health records for pregnancy safety surveillance holds the prospect of both reducing the burden and increasing the quality of the information gleaned from these studies. However, having a mother with depressive symptoms was associated with higher ED expenditures and higher predicted healthcare expenditures in a population of children who comprise over three-fourths of the top decile of Medicaid spending. About 940 sumatriptan‐exposed, 35 naratriptan‐exposed and 68 sumatriptan/naproxen‐exposed pregnancy outcomes were included in the retrospective claims analysis while the corresponding numbers for the pregnancy exposure registry analysis were 96 for sumatriptan, 5 for naratriptan, and 1 for sumatriptan/naproxen. Gender and ethnicity distributions were similar between the NAMCS and the CEMR. IBM MarketScan ® online query tools help you to improve the quality of your research – answering important business questions quickly.. With strong longitudinal integrity and cross-sectional depth, linked data across the MarketScan ® family of databases cover the full continuum of healthcare in the US. About 5120 pregnancies were identified in the retrospective claims cohort in contrast to 617 included in the prospective registry during the same time frame. It is possible that cancer in the elderly is being managed or treated differently than in their younger counterparts. Also, under/overestimation of major birth defects would occur if infants with major congenital malformations differentially disenrolled from insurance coverage during the first year of life relative to infants without these birth defects. We highlight opportunities to improve initial HTN treatments and treatment patterns associated with higher risk among HTN patients. The Truven Health MarketScan Commercial Claims and Encounter Database and the Medicare Supplemental and Coordination of Benefits Database (Truven Health Analytics Inc, Ann Arbor, MI) included data from January 1, 2007, to September 30, 2015. Databases. We identified 1 162 747 gout patients. The study population included women with a diagnosis of migraine (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD‐9‐CM] diagnosis codes 346.xx) or prescription claims for migraine‐specific acute medications (triptans or ergotamine‐derivatives) between January 1, 1996 and September 19, 2012 (see Appendix S1 for a full description of the migraine case finding algorithm). This study aimed to assess the generalizability and representativity of the widely used US Centricity Electronic Medical Record (CEMR), a primary and ambulatory care EMR for population health research, using data from the National Ambulatory Medical Care Surveys (NAMCS) and the National Health and Nutrition Examination Surveys (NHANES). It contains complete information on inpatient prescriptions, as well as links to outpatient prescription data. Of 25 481 patients who underwent colectomy, 4160 were included in the study. Possible reasons for patients not receiving 2 L treatment include still being on 1 L treatment, no requirement for 2 L treatment, refusal of treatment and death, although these cannot be reliably obtained from the claims database We conducted a multicenter cross sectional study in 5 Spanish regions. There were very few non‐livebirth outcomes in both the claims analyses and registry. Materials and Methods In conclusion, the findings of this study show that a sizable cohort of pregnant women exposed to medications of interest can be assembled using existing electronic health care databases. Truven Health Analytics, an IBM Company Truven Health MarketScan® Research Databases All Truven Health MarketScan® Research Database projects are subject to a data use agreement. As with any observational study conducted within the context of an insurance claims database, drug exposure and timing of exposure is never entirely certain. Background: Statistical analyses of the most recent data are necessary to guide GI research, education, and clinical practice. The inherent complexity of AD may challenge this reductionist strategy. In this study, live‐born infants linked to their birth mothers were required to have 12‐month continuous insurance enrolment beginning from the delivery date. Gout is the most common inflammatory arthritis in the United States. Truven MarketScan Database: Annual Cost Per Patient is average amount paid for any healthcare claim within 365 days for: 1) patients with at least two lab results within the same A1C range; and 2) patients with four lab results within the same A1C range. Professor of Medicine, Epidemiology, Health Policy and Management. Marketscan® Commercial Claims and Encounters and Medicare Supplemental Databases. The increasing use of electronic health records (EHRs) and biobanks offers unique opportunities to study Mendelian diseases. Out of 111 170 patients, the percentage of patients with any warfarin drug decreased slightly from 91.7% (95% CI: 91.0, 92.4) in early 2003 to 87.1% (95% CI: 86.7-87.6) in late 2009 (χ(2) = 93.8, p < 0.0001). Objective: Outline • MarketScan ® Commercial Claims and Encounters - nuts and bolts • Examples of use • Next steps. The dose-response analyses demonstrated no significant association with metformin dose, duration, or total exposure.CONCLUSIONS Overall, there was broad agreement between the findings of the claims analysis and the registry. The algorithm used for identification of pregnancy episodes and outcomes in this claims analysis has been shown to be very robust for livebirths, with almost complete agreement between claims and chart review, and less robust for non‐livebirth outcomes.9 While valid determination of gestational age is essential for assigning trimester of medication exposure, for abortions and stillbirths, ascertainment of gestational age is very challenging. Methods: Utilizing the Truven Marketscan ® research database, 554,806 patients who underwent cholecystectomy in calendar years 2011-2014 were identified using ICD-9 procedure and diagnosis codes. © 2008-2020 ResearchGate GmbH. Pharmacy commercial claims databases are widely used for pharmacoepidemiologic research. Conclusions: This research may find broad applications for phenomic studies of Mendelian disease genes. Outcomes included 90-day complications, emergency department visits, and readmissions. Common GI diagnosis ( 8.9 million visits ), opportunity exists to improve ( current ) HTN... February 1, 2015, using MarketScan data also contain diagnoses which can be used compare... > 80 years had a significantly higher proportion of iron testing and abdominal symptoms the! Au - Kulaylat, Audrey S. au - Kulaylat, Audrey S. au - Hollenbeak, Christopher PY. Individuals, 37 billion Service records, more than 160 contributing employers … Truven MarketScan is. 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